abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

journal_title：European journal of clinical pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS:A randomized, double-blind, cross-over study design with two phases, which were separated by a washout pe...

journal_title：European journal of clinical pharmacology

authors： Kantola T,Kivistö KT,Neuvonen PJ

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:The study was conducted to investigate whether oral co-administration with citrus juices significantly affects the pharmacokinetics and/or pharmacodynamics of pranidipine, a new 1,4-dihydropyridine calcium antagonist, in healthy male subjects. Grapefruit juice and orange juice, which were both commercially a...

journal_title：European journal of clinical pharmacology

authors： Hashimoto K,Shirafuji T,Sekino H,Matsuoka O,Sekino H,Onnagawa O,Okamoto T,Kudo S,Azuma J

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVES:This study was conducted to examine a complex effect of ciprofibrate therapy in patients with atherogenic lipoprotein phenotype. METHODS:Effects of ciprofibrate were studied on HDL subpopulations, HDL ability to esterify cholesterol (FER(HDL)), susceptibility of LDL to oxidation as well as on in vivo oxidat...

journal_title：European journal of clinical pharmacology

authors： Raslová K,Dobiásová M,Nagyová A,Fábry R,Rauchová H,Dusinská M

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was investigated in patients with septic shock. METHODS:Blood was sampled at intervals before, during and after 12-h infusion of L-NAME 1 mg x kg(-1) x h(-1) in nine septic shock patients for det...

journal_title：European journal of clinical pharmacology

authors： Avontuur JA,Buijk SL,Bruining HA

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:Troglitazone is an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which has been shown to improve the metabolic control of type 2 diabetes. Troglitazone undergoes hepatic metabolism to an inactive sulphate conjugate and an oxidative quinone metabolite with minor activity. The ob...

journal_title：European journal of clinical pharmacology

authors： Ott P,Ranek L,Young MA

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To study the effect of cisplatin on plasma concentrations and urinary excretion of carnitine in ten patients with different malignancies treated with chemotherapy. METHODS:Carnitine concentrations were determined using a radioenzymatic assay and other metabolites by routine methods of clinical chemistry. Ren...

journal_title：European journal of clinical pharmacology

authors： Heuberger W,Berardi S,Jacky E,Pey P,Krähenbühl S

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Spontaneous reporting is the most common method used in pharmacovigilance and the best one to generate signals on new or rare adverse drug reactions (ADRs). Under-reporting is a major drawback of this system. The objective of this study was to quantify the extent of under-reporting in general practice and to ...

journal_title：European journal of clinical pharmacology

authors： Alvarez-Requejo A,Carvajal A,Bégaud B,Moride Y,Vega T,Arias LH

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To determine the variability of coumarin 7- and 3-hydroxylation in a human population and to evaluate the evidence for the existence of genetic polymorphism in these pathways. 7-Hydroxylation of coumarin is considered to be a detoxication pathway, whilst 3-hydroxylation, which predominates in rats, leads to h...

journal_title：European journal of clinical pharmacology

authors： Hadidi H,Irshaid Y,Vågbø CB,Brunsvik A,Cholerton S,Zahlsen K,Idle JR

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:The primary objective was to evaluate the effect of 7 days treatment with nimesulide on bleeding time. Blood coagulation, von Willebrand factor and platelet aggregation ex vivo were investigated as a secondary objective. METHOD:A randomised, double-blind, placebo-controlled, parallel group, single centre stu...

journal_title：European journal of clinical pharmacology

authors： Marbet GA,Yasikoff Strub ML,Macciocchi A,Tsakiris DA

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in hypertensive patients. METHODS:Ten hypertensive patients on chronic verapamil treatment participated in a two-day study. On day 1 200 ml of water was given 1 hour before, and together with the morni...

journal_title：European journal of clinical pharmacology

authors： Zaidenstein R,Dishi V,Gips M,Soback S,Cohen N,Weissgarten J,Blatt A,Golik A

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Carvedilol, a beta-adrenoceptor blocking agent with additional alpha(1)-adrenoceptor blocking properties, has been shown to improve left ventricular function in chronic heart failure (CHF). However, its effect on mortality has recently been the subject of controversial discussion. The aim of this meta-analysi...

journal_title：European journal of clinical pharmacology

authors： Schmidt BM,Janson CP,Wehling M

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) is mediated by CYP2D6. The selective serotonin reuptake inhibitors (SSRIs) are known to inhibit CYP2D6. The aim was to study in vitro the potential inhibitory effect of SSRIs on metoprolol biotransformation. METHOD...

journal_title：European journal of clinical pharmacology

authors： Belpaire FM,Wijnant P,Temmerman A,Rasmussen BB,Brøsen K

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:The efficacy of beta-adrenergic blocking agents and acetylsalicylic acid in the secondary prevention of myocardial infarction has been well recognized since the beginning of the 1980s. In a previous paper, however, we reported a lower than expected use of these drugs during the period 1982 1988. In 1989 the r...

journal_title：European journal of clinical pharmacology

authors： Martínez M,Agustí A,Arnau JM,Vidal X,Laporte JR

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of rifampicin on the pharmacokinetics of itraconazole in humans. METHODS:Our study was conducted with six healthy normal volunteers and three AIDS patients. All subjects received a 200 mg single dose of oral itraconazole on day 1 and day 15 and 600 mg of oral rifampicin once daily ...

journal_title：European journal of clinical pharmacology

authors： Jaruratanasirikul S,Sriwiriyajan S

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD:The CYP2D6 phen...

journal_title：European journal of clinical pharmacology

authors： Monek O,Paintaud G,Bechtel Y,Miguet JP,Mantion G,Bechtel PR

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:Lamotrigine as add-on treatment (500 mg per day) is effective in patients with refractory epilepsy, but its high cost requires a pharmacoeconomic analysis. We conducted a retrospective lifetime cost utility study in which clinical data were derived from a recent placebo-controlled clinical trial, cost-of-illn...

journal_title：European journal of clinical pharmacology

authors： Messori A,Trippoli S,Becagli P,Cincotta M,Labbate MG,Zaccara G

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:The analgesic efficacy of intravenous doses of acetaminophen (paracetamol) 0.5 g, 1 g and 2 g (administered as propacetamol) was assessed in 11 healthy subjects in a randomised, double-blind, placebo-controlled crossover study. The antinociceptive effect was assessed over 8 h by measurement of the nociceptive...

journal_title：European journal of clinical pharmacology

authors： Piguet V,Desmeules J,Dayer P

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:A prospective study was undertaken to determine the transcorneal penetration of three topically applied fluoroquinolones into aqueous humour. METHODS:Two hundred and twenty-four patients undergoing cataract extraction received 0.3% ciprofloxacin, norfloxacin or ofloxacin eye drops by two different administra...

journal_title：European journal of clinical pharmacology

authors： von Keyserlingk J,Beck R,Fischer U,Hehl EM,Guthoff R,Drewelow B

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To assess the effect of an intervention on general practitioners' (GPs) knowledge about the diagnosis and treatment of asthma, including the prescribing of anti-asthmatic drugs, and asthmatic patients' knowledge about their disease. METHODS:The study took place in the south-west region of Stockholm County. I...

journal_title：European journal of clinical pharmacology

authors： Tomson Y,Hasselström J,Tomson G,Aberg H

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:We investigated whether interindividual differences in the pharmacokinetic disposition of lansoprazole are attributed to the genetic polymorphism of CYP2C19 which occurred by two mutations. CYP2C19m1 and CYP2C19m2, in 20 Japanese subjects. METHODS:Polymerase chain reaction (PCR) restriction fragment length p...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Nakamura C,Arimori K,Fujiyama S,Nakano M

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Because of the risk of haemorrhagic disease of the newborn as a result of a deficit in vitamin K, it is generally agreed that newborns should receive vitamin K. However, there is no consensus concerning the route of administration, dose, number of doses, or dose frequency. METHODS:We studied patterns of vita...

journal_title：European journal of clinical pharmacology

authors： Jonville-Bera AP,Autret E

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Iloprost is a potent PGI2 mimetic, which has been shown to be therapeutically effective in several vascular disorders. Due to its rapid clearance from the central compartment, iloprost is administered mainly by i.v. infusion, which limits its use to hospitalized patients. In order to improve pharmacotherapeut...

journal_title：European journal of clinical pharmacology

authors： Hildebrand M

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To study the effect of renal impairment on the pharmacokinetics of sertindole. METHODS:A single 4 mg oral dose of sertindole was given to normal subjects (n = 6) and subjects with various degrees of impaired renal function (n = 18) classified into mild, moderate, and severe/hemodialysis based on their creati...

journal_title：European journal of clinical pharmacology

authors： Wong SL,Menacherry S,Mulford D,Schmitz PJ,Locke C,Granneman GR

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:To analyse reports of drug-induced myocardial infarction and chest pain sent to a national reporting centre. To review which drugs were suspected of exhibiting these adverse events and what mechanisms were involved. METHODS:During the 20-year period 1975 through 1994, a total of 19,141 reports on adverse re...

journal_title：European journal of clinical pharmacology

authors： Ottervanger JP,Wilson JH,Stricker BH

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To determine the response of haemodynamic and oxygen-transport parameters to phenylephrine in a dose-response fashion in septic non-hypotensive, vasodilated surgical intensive care unit (ICU) patients. DESIGN:Prospective study. SETTING:Surgical ICU of a tertiary care, university medical centre. PATIENTS:Te...

journal_title：European journal of clinical pharmacology

authors： Flancbaum L,Dick M,Dasta J,Sinha R,Choban P

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study. RESULTS:Both oral and intramuscular artemether were well-tol...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Na-Bangchang K,Congpuong K,Molunto P,Thanavibul A

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To describe and compare the distribution of prescribed drugs in diabetic patients between 1992 and 1995. METHODS:Two cross-sectional surveys of a random selection of medical records of diabetic patients, from three community health centres (CHCs) in the Stockholm metropolitan area, were carried out. The age ...

journal_title：European journal of clinical pharmacology

authors： Wändell PE,Brorsson B,Aberg H

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Valsartan (V), a specific inhibitor of the angiotensin II receptor subtype, AT1, has been developed for treatment of hypertension. Combination therapy with a beta-adrenoceptor blocking agent might be considered in cases with insufficient efficacy of V alone. Therefore, an interaction trial was performed to ev...

journal_title：European journal of clinical pharmacology

authors： Czendlik CH,Sioufi A,Preiswerk G,Howald H

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:This study was performed to investigate whether it is possible to use saliva instead of blood usually used for therapeutic drug monitoring (TDM) of disopyramide. METHODS:Six healthy male volunteers ingested 200 mg of disopyramide base, and the disopyramide concentrations in saliva and plasma (total and unbou...

journal_title：European journal of clinical pharmacology

authors： Sagawa K,Mohri K,Shimada S,Shimizu M,Muramatsu J

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:This multicenter, double-blind, placebo-controlled, parallel-group study was designed to assess the acute effects of intravenous mibefradil on the electrophysiologic characteristics of the human heart. METHODS:Seventy-one patients referred for routine electrophysiologic testing were randomized to receive one...

journal_title：European journal of clinical pharmacology

authors： Rosenquist M,Brembilla-Perrot B,Meinertz T,Neugebauer A,Crijns HJ,Smeets JL,van der Vring JA,Fromer M,Kobrin I

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics of orally and intravenously administered valsartan were determined in two studies. In a first pilot study, three i.v. doses of valsartan were given in an ascending manner (5, 10 and 20 mg) to evaluate tolerability and basic pharmacokinetics of the i.v. formulation. In a second study, the ...

journal_title：European journal of clinical pharmacology

authors： Flesch G,Müller P,Lloyd P

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To examine the association between the sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer. METHOD:Meta-analysis of case-control studies using a random effects model. The "Main outcome measure" was the odds ratio for the risk of lung cancer, using extensive metabolisers as the ...

journal_title：European journal of clinical pharmacology

authors： Christensen PM,Gøtzsche PC,Brøsen K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To investigate the potential for pharmacokinetic interactions between moexipril, a new converting enzyme inhibitor, and hydrochlorothiazide after single dose administration. METHODS:12 healthy male volunteers were studied by an open, randomised, three-way cross-over design, in which single doses of moexipril...

journal_title：European journal of clinical pharmacology

authors： Hutt V,Michaelis K,Verbesselt R,De Schepper PJ,Salomon P,Bonn R,Cawello W,Angehrn JC

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:This paper describes a method to determine the number of patients and the number of blood levels which are appropriate for a pharmacokinetic population analysis. METHODS:We studied this question by performing 203 runs of population analysis, using the NPEM algorithm with a one compartment model, starting wit...

journal_title：European journal of clinical pharmacology

authors： Bréant V,Charpiat B,Sab JM,Maire P,Jelliffe RW

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:In the present randomized, fourway crossover study we determined the effects of two oral doses each of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man. METHODS:Twelve healthy female volunteers received for 2 consecutive days, followed by a 5-day drug-free interval, one of the...

journal_title：European journal of clinical pharmacology

authors： Stichtenoth DO,Tsikas D,Gutzki FM,Frölich JC

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP > or = 115 mmHg). PATIENTS:The ages of the patients ranged from...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Afolabi MA,Balogun MO,Adigun AQ,Ajayi OE,Akintomide AO

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and ...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakashima M,Fujii M,Hamano K,Yasutomi M,Kodaira S,Kato T,Kotake K,Oka H,Masuike T

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The effect of age on the pharmacokinetics and pharmacodynamics of prazosin (alpha 1 adrenoceptor blocker) was studied in 20 healthy volunteers. PATIENTS:Ten elderly (61-81 y) and ten young (23-28 y) subjects were studied. All subjects received 1 mg of prazosin orally in a fasting state. Serial blood samples ...

journal_title：European journal of clinical pharmacology

authors： Andros E,Detmar-Hanna D,Suteparuk S,Gal J,Gerber JG

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Intragastric pH-metry is widely used to evaluate the efficacy of antisecretory drugs, but statistical interpretation of the measurements has not yet been standardised. METHODS:The effects of single morning (N = 9) or evening (N = 7) doses of the H2-receptor antagonist famotidine, 20 mg (QUAMATELR. Gedeon Ric...

journal_title：European journal of clinical pharmacology

authors： Hunyady B,Juricskay I,Nagy L,Garamszegi M,Vincze A,Mózsik G

更新日期：1996-01-01 00:00:00